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Jeanmarie Verchot

Verchot, Jeanmarie
Jeanmarie Verchot
Professor
Office:
129 IPGB
Email:
Phone:
979-845-1788
Undergraduate Education
1987 B.S. Genetics (Molecular) Cook College at Rutgers University
Graduate Education
1991-1995 Ph.D. Microbiology, Texas A&M University

Molecular Plant Virology

My research focuses on two major fields of virus-host interactions.

First we study RNA virus interactions with cellular membranes.  Plant cells have an amazing ability to adapt and survive the impacts of virus infection.  Cellular membranes provide a network for communication with all parts of the cell.  Membranes vesicles transport cargo to various locations within and the cell as well as depositing cargo outside of the cell.  Membranes contain channels for ion signaling and sensors for activating changes in gene expression.  All RNA viruses depend upon cellular membranes as scaffolds for virus replication, encapsidation, and egress.  Creating these scaffolds requires significant rearrangement of cellular membranes.  Our investigations are to understand the cell adaptive machinery to the changes that viruses bring to cells.  We are particularly interested in the cellular adaptive machinery, known as the ER stress machinery, which is well conserved between plants and animals and humans.  The primary goal of our work is to understand how plant virus proteins at the ER manipulate cellular signaling to maintain a cellular environment that is favorable for infection.

 

Second, we are developing a new program to investigate the molecular mechanisms governing rose rosette virus infection.  We have developed an infectious clone technology and use Arabidopsis and roses to study the genetic basis of infection.

Honors and Awards

2019                Fellow of the Institute of Plant Genomics and Biotechnology, Texas A&M University

2015                Regents Distinguished Researcher Award from Oklahoma State University

 

National Service

2017-2020       Councilor for Plant Virology to the American Society of Virorology

2013-2015                   President, OSU Sigma XI chapter

2015-2021            Senior Editor for Molecular Plant Pathology Journal

Publications

  1. Aranda, MA, Makinen, K, and Verchot J (2019).  Introduction to Special Issue of Molecular Plant Pathology:  Extracellular and intracellular perception of plant viruses, Molecular Plant Pathology.   DOI: 10.1111/mpp.128 42
  2. Wijayasekara, D, Hoyt, P., Thapa, A, and Verchot, J (2018). Combining Analysis of DNA in a Crude Virion Extraction with the Analysis of RNA from Infected Leaves to Discover New Virus Genomes. http://www.jove.com/video/57855.
  3. Wijayasekara, D, Hoyt, P., Gimondo, A, Dunn, B, Thapa, A, Jones, H, and Verchot, J (2018). Molecular characterization of two badnavirus genomes associated with Canna yellow mottle disease. Virus Research 243, 19-24.
  4. Gaguancela, OA, Zuniga, LP, Arias, AV, Halterman, D, Flores, FJ, Johansen, IE, Wang, A, Yamaji Y, and Verchot J (2016).  The IRE1/bZIP60 pathway and bax inhibitor 1 suppress systemic accumulation of potyviruses and potexviruses in Arabidopsis and Nicotiana benthamiana plants.   Molec Plant Microbe Interact. 29: 750-766.
  5. Verchot J (2016) Plant virus infection and the ubiquitin proteasome machinery:  Arms race along the endoplasmic reticulum.   Viruses, 8(11), 314; doi:3390/v8110314
  6. Verchot, J. (2016) How does the stressed-out ER find relief during virus infection?  Current Opinion in Virology 17: 74-79.
  7. Zhang, L, Chen H, Brandizzi, F, Verchot J, Wang A (2015).  The UPR branch IRE1-bZIP60 in plants plays an essential role in viral infection and is complementary to the only UPR pathway in yeast.  PLoS Genet. 2015 11(4):e1005164. doi: 10.1371/journal.pgen.1005164.
  8. Chauhan RP, Rajakaruna, P, and Verchot J (2015).  Complete genome sequence of nine isolates of canna yellow streak virus reveals its relationship to the sugarcane mosaic virus (SCMV) subgroup of potyviruses.  Archives of Virol.  160: 837-844.