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Dr. Karen-Beth G. Scholthof

Scholthof, Dr. Karen-Beth G.
Dr. Karen-Beth G. Scholthof
Professor, Plant Virology
Graduate Education
Ph.D., Plant Pathology (1989) University of Kentucky

Molecular Plant Virology

My molecular plant virology research is on a virus complex of Panicum mosaic virus (PMV) and its satellite virus (SPMV). For molecular genetic studies on the PMV/SPMV virus:host interactions we are using the model grass, Brachypodium distachyon. Our current research focus includes investigations into the mechanism by which SPMV capsid protein (CP) localizes to the nucleolus, how host proteins facilitate this trafficking, and how SPMV and PMV induce host responses to infection. My second area of research is the historiography of Tobacco mosaic virus (TMV) in the early 20th century in the United States. My research and writing on the history of plant virology has been incorporated into graduate and undergraduate courses.



I teach the following courses in the Bioenvironmental Sciences (BESC) Program: Pathogens, the Environment, and Society (BESC 314), Field Experience  (BESC 484), and a Capstone Seminar (BESC 481). I am the Faculty Director of BESC Undergraduate Honors Program.


Recent Publications

Pyle, J.D., Mandadi, K.K., and Scholthof, K.-B.G. 2019. Panicum mosaic virus and its satellite acquire RNA modifications associated with host-mediated viral degradation. mBio10:e01900-19.

Pyle, J.D., and Scholthof, K.-B.G. 2018. De novo generation of helper virus-satellite chimera RNAs results in disease attenuation and satellite sequence acquisition. Virology 514:182-191.

Scholthof, K.-B.G., Irigoyen, S.C., Catalan, P., and Mandadi, K.K. 2018. Brachypodium: A monocot grass model system for plant biology. Plant Cell 30:1673-1694.

Scholthof, K.-B.G. 2017. Spicing up the N gene: F. O. Holmes and Tobacco mosaic virus resistance in Capsicum and Nicotiana plants. Phytopathology 107: 148-157.

Scholthof, K.-B.G. 2015. Finding our roots and celebrating our shoots: An examination of formative plant virus articles in Virology, 1955-1964. Special Issue: 60th Anniversary. Virology, 479-480: 345-355.

Mandadi, K. K., and Scholthof, K.-B.G. 2015. Genome-wide analysis of alternative splicing landscapes modulated during plant-virus interaction in Brachypodium distachyon. Plant Cell 27: 71-85.

Scholthof, K.-B.G. 2014. Making a virus visible: Francis O. Holmes and a biological assay for Tobacco mosaic virus. Journal of the History of Biology. 47:107-145.