Carlos F. Gonzalez

Areas of Expertise

1. Yao, G.W., Duarte, I, Tram T. Le, T. T., Carmody, L., LiPuma, J. J., Young, R., and Gonzalez, C.F. 2017. A Broad Host Range Tailocin from Burkholderia cenocepacia. Appl Environ Microbiol 83:e03414-16. https://doi.org/10.1128/AEM.03414-16.
2. Bhowmick, T.S., M. Das, K. M. Heinz, P.C. Krauter, C. F. Gonzalez. 2016. Transmission of phage by glassy-winged sharpshooters, a vector of Xylella fastidiosa. Bacteriophage. DOI: 10.1080/21597081.2016.1218411
3. Das M., Bhowmick, T.S., Ahern S.J., Young R., Gonzalez C.F. 2015. Control of Pierce’s Disease by Phage. PLoS ONE 10(6): e0128902. doi:10.1371/journal.pone.0128902
4. Ahern, S. J.  M. Das, T. Bhowmick, R. F. Young, III, C. F. Gonzalez. 2014. Characterization of Novel Virulent Broad-Host-Range Phages of Xylella fastidiosa and Xanthomonas. J. Bacteriol. 196:459-471
5. Gill, J.J, E. J. Summer, W. K. Russell, S. M. Cologna, T. M. Carlile, A. C. Fuller, K. Kitsopoulos, L. M. Mebane, B. N. Parkinson, D. Sullivan, L. A. Carmody, C. F. Gonzalez, J. J. LiPuma, R. Young. 2011. Genome and characterization of phages Bcep22 and BcepIL02, founders of a novel phage type in Burkholderia cenocepacia. J. Bacteriol.193:5300-5313.
6. Carmody, L. A, J.J. Gill, E.J. Summer,U. S. Sajjan,C. F. Gonzalez,R. F. Young, and J. J. LiPuma. 2010. Efficacy of Bacteriophage Therapy in a Model of Burkholderia cenocepacia Pulmonary Infection. J. Infect. Dis. 201:264-271.
7. Summer, E. J., C. J. Enderle, S. J. Ahern, J. J. Gill, C. P. Torres, D. N. Appel, M. C. Black, R. Young, and C. F. Gonzalez. 2010. Genomic and Biological Analysis of Phage Xfas53 and Related Prophages of Xylella fastidiosa. J. Bacteriol 192:179-190.
8. Zhang, R., J. J. LiPuma, and C. F. Gonzalez. 2009. Two type IV secretion systems with different functions in Burkholderia cenocepacia K56-2. Microbiology 155:4005-13.
9. Sajjan, S. U., L. A. Carmody, C. F. Gonzalez, and J. J. LiPuma, 2008. A Type IV Secretion System Contributes to Intracellular Survival and Replication of Burkholderia cenocepacia. Infect. Immun. 76:5447-5455.
10. Summer, E.J., Gill, J. J., Upton, C., Gonzalez, C.F. and Young, R. F. 2007. Role of phages in the pathogenicity of Burkholderia, or, ‘where are the toxin genes in Burkholderia phages?’ Current Opinion in Microbiology 10: 410-17.
11. Summer, E.J., C. F. Gonzalez, M. Bomer, T. Carlile, A. Embry, A. M. Kucherka, J. Lee, L. Mebane, W. C. Morrison, L. Mark, M. D. King, J.J. LiPuma, A. K. Vidaver, and R. Young. 2006. Divergence and mosaicism among virulent soil phages of the Burkholderia cepacia complex. J. Bacteriol. 188:255-268.

Professional Summary

Plant Bacteriology

Research in my laboratory encompasses a range of studies that address the genetics of virulence and pathogenicity. The model systems used in our studies are members of the Burkholderia Cepacia Complex (BCC) composed of nine species. The BCC are recognized as significant pathogens in cystic fibrosis patients. We are currently studying secretion systems responsible for export of a cytotoxic protein(s) in both B. cepacia (plant pathogen) and B. cenocepacia (human pathogen) to determine common mechanisms for pathogenicity. In addition we are conducting genomic analysis of BCC bacteriophage.