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Assistant Professor, Plant Molecular Biology
132A Borlaug
979-845-8818
lshan@tamu.edu
Education
Post-Doctoral: Harvard Medical School
Ph.D.: Kansas State University
B.S.: Beijing Normal University
Research Emphasis:
Plant Molecular Biology
We and plants detect "danger" by recognizing microbe-associated molecules and launch complex innate immune signaling to prevent infection. Successful pathogens, however, have evolved multiple sophisticated virulence strategies to dampen the host immunity and result in infection. My research interest is to understand the genetic, molecular and biochemical mechanisms of the dynamic host-microbe interactions using Arabidopsis-Pseudomonas as a model plant-pathogen system. My ultimate goal is to understand how the host-microbe interactions shape the evolution of microbial pathogenicity and plant immunity in both model and economically important plants.
Recent Publications
Shan, L., He, P., Li, J., Heese, A., Peck, S. C., Nurnberger, T., Martin, G. B., and Sheen, J. (2008). Bacterial effectors target the common signaling partner BAK1 to disrupt multiple MAMP receptor-signaling complexes and impede plant immunity. Cell Host & Microbe 4, 17-27.
Chen, Z., Agnew, J., Cohen, J., He, P., Shan, L., Sheen, J., and Kunkel, K. (2007) The Pseudomonas syringae type III effector AvrRpt2 alters Arabidopsis thaliana auxin physiology. Proc. Natl. Acad. Sci. U. S. A 104: 20131-20136.
Shan, L., He, P., and Sheen, J. (2007) Intercepting host MAPK signaling cascades by bacterial type III effectors. Cell Host & Microbe 1: 167-174.
He, P., Shan, L., and Sheen, J. (2007) Elicitation and suppression of MAMP-triggered immunity in plant-microbe interactions. Cell Microbiol 9: 1385-1396.
Shan, L., He, P., and Sheen, J. (2007) Endless hide-and-seek: dynamic coevolution in plant-bacterium warfare. Journal of Integrative Plant Biology 49:105-111.